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KMID : 0357419950250020181
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Korean journal of Virology
1995 Volume.25 No. 2 p.181 ~ p.188
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The Change of Intracellular pH following Infection with Human Cytomegalovirus
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Abstract
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Infection of human embroy lung (HEL)cells with human cytomegalovirus (HCMV) resulted in change of intracellular pH([pH]i). A maximal increase in [pH]i was observed at 12 hr postinfection (p.i.) in HCMV-infected HEL cells. Inactivation of HCMV
with
heat
treatment or UV irradiation effectively abolished the HCMV-induced increase in [pH]i observed at 12 hr p.i. in HEL cells. And the degree of the increase in [pH]i was dependent on the amount of infectious virus. Treatment of HCMV-infected HEL
cells
with
amiloride, an inhibitor of Na+/H+ exchanger, partially blocked the increase in [pH]i. These results suggest a possible relationship between the change of intracellular pH and HCMV replication.
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